Born and raised in St. Louis, Dr. Perschbacher received his undergraduate degree from the University of Notre Dame, followed by his medical degree from St. Louis University in 2001. He then moved to Rochester, Minnesota where he completed his residency in Internal Medicine at the Mayo Clinic. Returning 'home' in 2004, he completed his fellowship in Cardiology at Barnes-Jewish Hospital at Washington University School of Medicine.

Dr. Perschbacher is board certified in Internal Medicine and Cardiovascular Disease. He maintains affiliations with several medical organizations including the American College of Cardiology, the American Heart Association, and the American Society of Echocardiography.

Having trained as an invasive, non-interventional cardiologist, Dr. Perschbacher specializes in general cardiology with an emphasis in cardiac imaging, particularly nuclear cardiology and echocardiography (including stress echocardiography and transesophageal echocardiography). His interests include valvular heart disease, coronary artery disease, and preventive cardiology.